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--- nhs uk medicines common-questions-about-tibolonePeople also askWhat are the Common side effects of tibolone? Does tibolone affect body composition? patient info medicine tibolone-tablets-livialchanges in your periods, including spotting or bleeding between periods headaches breast pain or tenderness feeling sick (nausea) diarrhoea feeling tired or dizzy mood changes, including low mood or depression mild rash or itchy skin acne See full list on academic oup com Does tibolone increase TBW? --- mskcc org cancer-care patient-education medications adult tibolone The major side effect was weight gain and or a tendency to bloating and oedema which occurred in 11 28% of our women Vaginal bleeding occurred in 33 women (12 69%) but in 17 of these women the bleeding was due to recent oestrogen therapy Livial® Available as Tablets Tibolone works by mimicking the activity of the female sex hormones, oestrogen and progesterone It also has some male hormone (androgen) effects Tibolone helps to restore the balance of female hormones in women who have a lack of oestrogen; it helps to ease symptoms such as hot flushes and night sweats --- nhs uk medicines side-effects-of-tibolone--- nhs uk medicines side-effects-of-hormone-replacement-therapy-hrt--- nejm org doi full 10 1056 NEJMoa0800743Does tibolone cause weight gain? As compared with placebo, tibolone was associated with a mean increase in weight of 0 6 kg; 109 of 2050 women (5 3%) in the tibolone group and 81 of 2121 (3 8%) in the placebo group gained at Tibolone has not been shown to protect against MI in women with or without existing coronary artery disease (CAD) In general, use of combined estrogen-progestogen hormone replacement therapy (HRT) is associated with slight increase of CAD in patients >60 years of age; use caution with tibolone in this population Oct 12, 2016 · In brain and liver, tibolone seems to have androgenic effects Some randomised controlled clinical trials (RCTs) have suggested that tibolone decreases vasomotor symptoms and ameliorates vaginal dryness and discomfort, but results are not consistent Aug 14, 2008 · As compared with placebo, tibolone was associated with a mean increase in weight of 0 6 kg; 109 of 2050 women (5 3%) in the tibolone group and 81 of 2121 (3 8%) in the placebo group gained at Overall tibolone was well tolerated and climacteric symptoms were relieved within 3-5 weeks The major side effect was weight gain and or a tendency to bloating and oedema which occurred in 11 28% of our women Vaginal bleeding occurred in 33 women (12 69%) but in 17 of these women the bleeding was due to recent oestrogen therapy The oestrogenic effects, exerted mainly in brain, bone and vaginal tissues, are weaker on the endometrium, where the drug is transformed into progestogen metabolites In breast tissue, limited conversion of oestrone to oestradiol may reduce the oestrogenic effects In brain and liver, tibolone seems to have androgenic effects Tibolone can sometimes cause weight gain However it's also common to put on weight around the time of the menopause and as you get older, so it might not be your medicine that's causing it Eating a healthy, balanced diet and regular exercise will help you keep to a healthy weight academic oup com endo article 142 11 4813 2988934pubmed ncbi nlm nih gov 7731388--- ncbi nlm nih gov pmc articles PMC6458045Weight gain or loss Change in sex interest Muscle or joint pain Feeling nervous and excitable Pimples (acne) Hair growth Hair loss These are not all of the side effects that may occur If you have questions about side effects, call your doctor Call your doctor for medical advice about side effects You may report side effects to your BODY WEIGHT INCREASES with age in both men and women Whether the rate of weight gain is influenced by the occurrence of the menopause is not clear Although many women report that they gained weight at or near the time of their menopause, the amplitude and even the reality of the menopause-related gain in weight remain controversial (1) Body comp Does tibolone affect body composition in postmenopausal women? Tibolone is a synthetic (artificial) hormone It may be recommended if you prefer not to take oestrogen or have problems with side effects Some studies have suggested it may not be as effective as combined HRT Tibolone only comes as tablets Some other types of HRT are available as tablets, capsules, patches, gel or spray Weight gain and HRT There's little evidence that most types of HRT make you put on weight You may gain some weight during the menopause and as you get older, but this often happens whether you take HRT or not Exercising regularly and eating a balanced diet should help you to manage your weight More serious risks Does tibolone increase fat-free mass? The issue of weight gain is important not only because of aesthetic considerations, but also because body FM and its distribution correlate with risks of coronary artery disease and certain cancers The drug used in our trial, tibolone (2 5 mg), is a tissue-specific compound associated with estrogenic, progestogenic, and androgenic activities --- drugs com ppa tibolone html Will I gain or lose weight? Weight gain can be a side effect of taking tibolone However, it's also common to gain weight around the time of the menopause, so it may not be your medicine that's causing you to put on weight These common side effects of tibolone happen in more than 1 in 100 people There are things you can do to help cope with them: Breast tenderness Stomach pain or pelvic pain Unusual hair growth Vaginal bleeding or spotting Putting on weight Speak to a pharmacist or doctor if the advice on how to cope does not help and a side effect is still
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