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Spedra contains the active substance avanafil How is Spedra used? Spedra is available as tablets (50, 100, and 200 mg) and can only be obtained with a prescription Avanafil was approved for the treatment of ED in the US and Europe in 2012 and 2013 9 This drug also has the advantages of rapid onset of action (Tmax 35 min) and short half-life (< 1 5 h) compared to other PDE5 inhibitors 10 It works by mediating the breakdown of cyclic guanosine monophosphate (cGMP), inducing smooth muscle relaxation in the --- nice org uk advice esnm45 chapter full-evidence-summaryAvanafil is a highly selective and potent, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by avanafil produces increased levels of cGMP in the corpus cavernosum of the penis --- ncbi nlm nih gov pmc articles PMC10362898Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 and by EMA on June 21, 2013 Avanafil is sold under the brand names Stendra and Spedra It was invented at Mitsubishi Tanabe Pharma, formerly known as Tanabe Seiyaku Co , [4] and licensed to Vivus Inc , which partnered with Menarini Group to pubmed ncbi nlm nih gov 27416913Data synthesis Avanafil is a highly selective PDE5 inhibitor that is a competitive antagonist of cyclic guanosine monophosphate Specifically, avanafil has a high ratio of inhibiting PDE5 as compared with other PDE subtypes allowing for the drug to be used for ED while minimizing adverse effects Aug 12, 2014 · Avanafil received a European marketing authorisation for the treatment of erectile dysfunction in adult men in June 2013 and was launched in the UK in March 2014 The current marketing authorisation states that avanafil should be taken approximately 30 minutes before sexual activity --- ncbi nlm nih gov pmc articles PMC3433322Aug 12, 2014 · According to the European public assessment report for avanafil, response rates generally decreased as the severity of erectile dysfunction increased The open‑label long‑term extension study suggests that the effects of avanafil are maintained for up to 52 weeks --- ncbi nlm nih gov pmc articles PMC4542406--- tandfonline com doi full 10 2147 TCRM S419408 “Spedra - avanafil ”, a medicinal product for human use (Text with EEA relevance) (ONLY THE FRENCH TEXT IS AUTHENTIC) THE EUROPEAN COMMISSION, Having regard to the Treaty on the Functioning of the European Union, Having regard to Regulation (EC) No 726 2004 of the European Parliament and of the Avanafil ( Spedra) received a European marketing authorisation for the treatment of erectile dysfunction in adult men in June 2013 and was launched in the UK in March 2014 The current marketing authorisation states that avanafil should be taken approximately 30 minutes before sexual activity At the time of its release in the European Union and US, avanafil had been evaluated in approximately 1,300 patients 11 The medication was termed as a second-generation PDE5I with a higher selectivity for PDE5 versus other agents that had additional attraction to other subtypes of PDE receptors With increased selectivity, it was hoped that A total of 1774 patients received avanafil , which was taken as needed at doses of 50 mg (one study), 100 mg and 200 mg (four studies), respectively Patients were instructed to take 1 dose of study medicinal product approximately 30 minutes prior to initiation of sexual activity avanafil On 25 April 2013, the Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending the granting of a marketing authorisation for the medicinal product Spedra, 50 mg, 100 mg, 200 mg, tablet intended for the treatment of erectile dysfunction in adult men Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 and by EMA on June 21, 2013 Avanafil is sold under the brand names Stendra and Spedra Spedra has been studied in three main studies involving over 3,400 men with erectile dysfunction The first study involved men from the general population, but because certain conditions associated with erectile dysfunction might affect response to treatment the second study looked mainly at men who had erectile dysfunction and diabetes, and the third was in men who had erectile dysfunction europepmc org article MED 24259695Avanafil is a medication that was recently approved by the US Food and Drug Administration for the management of erectile dysfunction Avanafil is a new phosphodiesterase type 5 inhibitor similar to sildenafil and tadalafil Avanafil was studied in over 1300 patients during clinical trials, including patients with diabetes mellitus and those --- ema europa eu en documents spedra-epar-product-information_en pdf--- ema europa eu en medicines human EPAR spedraAvanafil, the only United States and European Union-approved second-generation PDE5 inhibitor, is a safe and efficacious alternative to its predecessors Areas covered: We reviewed the current and most up-to-date literature regarding Avanafil, as well as the pivotal trials that measured efficacy and tolerability As Avanafil is still a en wikipedia org wiki AvanafilAvanafil has been identified to be a promising treatment for ED Avanafil was approved for the treatment of ED in the US and Europe in 2012 and 2013 Citation 9 This drug also has the advantages of rapid onset of action (Tmax 35 min) and short half-life (< 1 5 h) compared to other PDE5 inhibitors

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